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相关实验视频

Updated: Jun 20, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Published on: June 14, 2016

抑制 ангиотензин转化酶会改变对心肺旁路的纤维解质反应.

Mias Pretorius1, Laine J Murphey, Julie A McFarlane

  • 1Department of Anesthesiology, Vanderbilt University, Nashville, Tenn, USA. mias.pretorius@vanderbilt.edu

Circulation
|December 6, 2003
PubMed
概括

手术前的血管酶转化酶 (ACE) 抑制降低了冠状动脉旁路移植 (CABG) 后的等离子体激活剂抑制剂-1 (PAI-1) 水平. 这表明ACE抑制可能有助于预防急性移植血栓形成.

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Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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科学领域:

  • 心血管外科心血管外科
  • 药理学 药理学是指药理学的学科.
  • 血栓形成研究研究

背景情况:

  • 升高的血原激活剂抑制剂-1 (PAI-1) 在冠状动脉旁路移植 (CABG) 后与静脉移植封闭相关.
  • 众所周知, ангиотензин II 刺激了 PAI-1 的表达.

研究的目的:

  • 调查手术前的血管酶转化酶 (ACE) 抑制是否可以降低CABG后的PAI-1表达.

主要方法:

  • 接受CABG的31名患者随机分配到继续ACE抑制剂 (ACEI) 治疗或在手术前48小时停止治疗.
  • 在手术前,心肺绕道 (CPB) 期间和术后第一天 (POD1) 采集了血液样本,以测量PAI-1和组织类型等离子体激活剂 (tPA).

主要成果:

  • CPB最初降低了PAI-1,但它增加了POD1 (P<0.001).
  • ACEI治疗减弱了POD1上PAI-1的增加 (P=0.013) 和与基线的整体变化 (P=0.009).
  • 虽然手术期间的tPA活性没有显示差异,但ACEI组在术后的tPA活性显著增加 (P=0.030).

结论:

  • 手术前的ACE抑制有效地降低了PAI-1在CABG后的增加.
  • 这些发现支持ACE抑制在减轻CABG后急性移植血栓形成风险方面的潜在作用.