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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
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在缺血性阿波利波蛋白E-Knockout小鼠中移植骨髓衍生的单核细胞可以加速动脉样硬化,而不会改变斑块组成.

Jean-Sébastien Silvestre1, Andrea Gojova, Valérie Brun

  • 1Institut National de la Santé et de la Recherche Médicale U541, Hôpital Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France.

Circulation
|December 6, 2003
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概括

骨髓衍生单核细胞 (BM-MNCs) 促进新血管化,但在缺血性疾病中可能加速动脉样硬化进展. 需要进一步的研究来评估心血管疾病患者的长期安全性和疗效.

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科学领域:

  • 再生医学是一种再生医学.
  • 心血管研究研究心血管研究
  • 细胞疗法细胞疗法

背景情况:

  • 骨髓衍生单核细胞 (BM-MNCs) 正在研究它们在缺血后增强新血管化的潜力.
  • 在动脉样硬化的背景下,BM-MNC治疗的安全性尚未完全阐明.

研究的目的:

  • 评估BM-MNC移植在缺血环境下对动脉样硬化进展的安全性和影响.
  • 评估BM-MNCs对apolipoprotein E-knockout (apoE-KO) 小鼠新血管化和动脉样硬化斑块发育的影响.

主要方法:

  • 阿波利波蛋白E-Knockout (apoE-KO) 的小鼠遭受了后肢缺血,并接受了盐水或BM-MNCs的治疗.
  • 动脉样硬化斑块的大小在大动脉鼻中被评估,在缺血后肢中评估了新血管化.
  • 测试了不同剂量的BM-MNC和自身的BM-MNC.

主要成果:

  • BM-MNC移植显著改善了缺血后肢的新血管化,通过增加血管造影得分,毛细血管密度和 perfusion.
  • 然而,在后肢缺血症的apoE-KO小鼠中进行BM-MNC移植,与对照组相比,动脉样硬化病变大小显著增加.
  • 没有观察到斑块组成或总胆固醇水平的显著变化.
  • 自主BM-MNCs没有显示出益血管性或益动脉性影响.

结论:

  • BM-MNC疗法可能会在缺血性疾病中促进动脉样硬化斑块的进展.
  • 短期的BM-MNC治疗不太可能影响动脉样硬化斑块的稳定性.
  • 需要进一步的研究,以了解BM-MNC治疗在动脉样硬化和缺血症患者的长期影响.