状分子囊用于疏水性化合物
Meredith T Morgan1, Michael A Carnahan, Chad E Immoos
1Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Journal of the American Chemical Society
|December 11, 2003
概括
聚 (甘油酸) 树枝体成功封装了里哈德特树枝体.
科学领域:
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 体是高度分支的宏分子,具有可调节的内部环境.
- 研究树枝状体内的微环境对于理解它们的特性和应用至关重要.
- 赖哈特染料是极性和局部介电常数的敏感探针.
研究的目的:
- 用封装的赖哈特染料来描述多 (甘油酸) 树枝状体的内部环境.
- 评估这些树枝状物作为水溶性较差药物的药物输送载体的潜力.
主要方法:
- 里哈特染料的封装在多 (甘油酸) 树脂体内 ([Gn]-PGLSA-OH).
- 光谱分析包括UV-Vis吸收,1H NMR,1H T1/T2放松时间,1H NOESY.
- 在碳氧化PGLSA树枝状体 ([G4]-PGLSA-COONa) 中封装10-基托素 (10HCPT).
- 在体外细胞毒性测定使用人类乳腺癌细胞.
主要成果:
- 封装的赖哈特染料表明树突体内具有很高的介电常数.
- 核磁共振 (NMR) 数据证实了染料在树突体内的近距离和受限运动.
- 封装的10HCPT对乳腺癌细胞表现出显著的细胞毒性,并保持其活性.
- 碳氧化树脂聚合物 ([G4]-PGLSA-COONa) 成功提供了抗癌药物.
结论:
- 聚 (甘油酸) 树枝膜为客分子提供了一个封闭的微环境.
- 这些树枝状体显示出希望作为有效的药物输送系统,用于疏水性抗癌剂.
- 封装的药物保留了其治疗功效,突出了基于树枝状分子的药物输送潜力.
相关概念视频
Solvents
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
A...
Cohesion
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...
On a surface,...
Molecular Shape and Polarity
Dipole Moment of a Molecule
Solubility
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Colloidal precipitates
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
Colligative Properties
When a solute is added to a pure solvent (A), the mole fraction of A decreases. The mole fraction is the ratio of the number of moles of A to the total number of moles in the solution. This decrease in mole fraction leads to a reduction in A's chemical potential (μA).The changes in μA also affect the solution's colligative properties. Colligative properties are properties of a solution that depend only on the number of solute particles present, not their identity. Examples include boiling point...


