在亚洲的人类taeniasis和 cysticercosis
Akira Ito1, Minoru Nakao, Toni Wandra
1Department of Parasitology, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, 078-8510, Asahikawa, Japan. akiraito@asahikawa-med.ac.jp
Lancet (London, England)
|December 12, 2003
概括
泰尼亚带虫感染,包括新发现的亚洲虫,对公共健康构成重大风险. 对有效疫苗和诊断工具的研究对于全球控制这些寄生虫疾病至关重要.
科学领域:
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 人类的虫病是由食用受污染的肉类后的Taenia solium (猪肉虫) 或Taenia saginata (牛肉虫) 引起的.
- 塔尼亚固体感染可能导致神经囊硬化症,这是一个严重的神经疾病.
- 亚洲地区流行的一种新发现的带状虫 (Taenia asiatica),使诊断和疾病控制变得复杂.
研究的目的:
- 审查分子和免疫学技术的进步,以区分taeniid物种.
- 突出需要进一步研究人类Taenia asiatica感染的临床意义和囊病的潜力.
主要方法:
- 审查最近的分子和免疫学研究在Taeniid cestode疫苗开发.
- 在有效的球疫苗中对常见的遗传特征进行分析,以对抗taeniid cestodes.
- 讨论开发动物模型的进展,以区分人类类物种.
主要成果:
- 在实验室和现场环境中,重组化球疫苗已经证明对各种taeniid cestodes具有很高的疗效 (近100%).
- 在有效的疫苗中发现的共同特征包括分泌信号序列和纤维菌素III型域.
- 在过去的十年中,分子和免疫技术取得了重大进展.
结论:
- 有效的疫苗和诊断工具对于控制病和预防囊病至关重要.
- 需要对亚洲的临床影响和公共卫生影响进行进一步的研究.
- 在分子和免疫学方法的持续研究将有助于区分和管理taeniid感染.
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