在富含胆固醇的饮食后,心脏缩和腹功能障碍
Y Huang1, K E Walker, F Hanley
1Department of Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pa 19107, USA.
Circulation
|December 17, 2003
概括
饮食性高胆固醇血症会导致胆固醇心肌病,损害心脏功能. 这项研究揭示了饮食与心脏功能障碍的直接联系,独立于血管疾病.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生化学
- 分子生物学分子生物学
背景情况:
- 高胆固醇血症是冠状动脉疾病的已知危险因素.
- 高胆固醇对心脏功能的直接影响仍然在很大程度上是未知的.
研究的目的:
- 调查饮食高胆固醇血症对心脏功能的直接影响.
- 阐明导致胆固醇引起的心脏功能障碍的分子机制.
主要方法:
- 子被养含有0.5%胆固醇的饮食10周.
- 评估了心脏功能,包括静心缩短和静心放松.
- 测量了sarcoplasmic/endoplasmic网膜中的Ca2+-ATPase (SERCA) - 2mRNA和蛋白质水平.
- 分析了髓重链 (MHC) 的mRNA比率和肉膜胆固醇含量.
主要成果:
- 胆固醇养损害了系统缩短和透缩放松率.
- 在4天内,SERCA-2 mRNA水平显著下降,随后蛋白质功能受损和摄入量减少.
- MHC-β与MHC-αmRNA的比率增加了五倍,表明心脏收缩率发生了变化.
- 这些心脏变化与心脏瘤中胆固醇增加有关.
结论:
- 饮食性高胆固醇血会引起一种独特的心脏功能障碍,称为"胆固醇心肌病".
- 观察到的缩和腹功能障碍是高胆固醇的直接后果,而不是血管疾病的次要原因.
- 这项研究确立了饮食与心脏功能障碍的直接联系,强调了心脏对胆固醇过载的脆弱性.
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