在人体头向上倾斜时肌肉间歇性
Soraya Samii1, Mazhar H Khan, David A MacLean
1Division of Cardiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pa 17033, USA.
Circulation
|December 24, 2003
概括
抬头倾斜 (HUT) 增加神经血管空间中的细胞外 ([Ca2+]o),可能导致外周血管收缩. 这项研究测量了在人体中HUT期间的in situ[Ca2+]o变化.
科学领域:
- 生理学 生理学 生理学
- 神经血管医学 神经血管医学
- 心血管研究研究心血管研究
背景情况:
- 在头向上倾斜 (HUT) 时,外周血管收缩是必不可少的.
- 交感神经末端和血管光滑肌肉细胞通信对于这种反应至关重要.
- 细胞外 ([Ca2+]o) 是需要这些细胞的激活和功能.
研究的目的:
- 调查假设细胞外 ([Ca2+]o) 水平在HUT期间增加的假设.
- 探索[Ca2+]o升高在调解外周血管收缩中的潜在作用.
主要方法:
- 在10名健康受试者的下肢骨肌中使用微透析技术.
- 测量在位细胞外 ([Ca2+]o) 度在头向上倾斜 (HUT) 的神经血管空间.
主要成果:
- 在HUT期间观察到透析物[Ca2+]显著增加62%.
- 测量的[Ca2+]o水平从0.223+/-0.018上升到0.353+/-0.028 mmol/L.
- 这是第一份关于在HUT过程中对人类进行实地[Ca2+]o测量的报告.
结论:
- 这些发现表明,在HUT期间神经血管空间[Ca2+]o大幅增加.
- 这种[Ca2+]o的增加可能促进细胞间相互作用,促进血管收缩.
- 需要进一步的研究来阐明这种[Ca2+]o短暂物对神经末和血管光滑肌肉细胞的特定影响.
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