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身体训练增加了内皮前代细胞,抑制了新内膜的形成,并增强了血管新生.

Ulrich Laufs1, Nikos Werner, Andreas Link

  • 1Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg, Germany. ulrich@laufs.com

Circulation
|December 24, 2003
PubMed
概括
此摘要是机器生成的。

身体活动通过一种依赖于氧化 (NO) 的抗瘤机制,增强内皮原生细胞 (EPC). 这种EPC的增加可能解释了运动对心血管疾病的益处.

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科学领域:

  • 心血管研究研究心血管研究
  • 运动生理学 运动生理学
  • 细胞生物学 细胞生物学

背景情况:

  • 身体训练改善心血管健康的机制,特别是外周和冠状动脉疾病,仍然不清楚.
  • 来自骨髓的内皮原生细胞 (EPC) 参与血管修复,血管生成和减轻动脉样硬化.

研究的目的:

  • 为了研究体育活动对骨髓衍生的内皮原生细胞 (EPC) 的影响.
  • 阐明氧化 (NO) 和亡在运动引起的EPC变化中的作用.
  • 评估运动对血管修复和新内形成的功能影响.

主要方法:

  • 小鼠接受了跑步轮协议 (5.1+/-0.8公里/天) 或静坐条件,EPC通过光激活细胞分类分析量化.
  • 研究包括使用N(G) -nitro-l-arginine甲基治疗的eNOS-/-小鼠和野生型小鼠,以评估NO依赖性.
  • 用动脉损伤和皮下磁盘血管生成模型来评估血管修复. 还分析了患有冠状动脉疾病,接受中度运动训练的患者数据 (n=19).

主要成果:

  • 身体活动显著增加了老鼠外周血液,骨髓和脏衍生的单核细胞中的循环EPCs.
  • 运动诱导的EPC增加在eNOS-/-小鼠和用N(G) -nitro-l-arginine甲基治疗的小鼠中减弱,表明没有依赖性.
  • 跑步抑制了neointima形成的22+/-2%,增加了新血管生成的41+/-16%.
  • 在患有冠状动脉疾病的患者中,运动训练增加了循环中的EPC,并减少了EPC亡.

结论:

  • 身体活动增强了EPCs的生产和流通.
  • 运动对心血管健康的有益影响可能由一个部分依赖NO的,涉及EPCs的抗瘤机制介导.
  • 研究结果表明,促进体育活动可能是改善血管功能和修复的策略.