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Updated: Jul 5, 2026

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

从分子动力学模拟和对接实验中确定β-分泌酶的活性位子质子化状态:对基于结构的抑制剂设计的影响

Hwangseo Park1, Sangyoub Lee

  • 1School of Chemistry and Molecular Engineering, and Center for Molecular Catalysis, Seoul National University, Seoul 151-747, South Korea. hwangseo@snu.ac.kr

Journal of the American Chemical Society
|December 25, 2003
PubMed
概括

在阿尔茨海默病中至关重要的Memapsin 2 (BACE) 具有模两可的酸质子化状态. 模拟显示Asp228,而不是Asp32,作为抑制剂的键受体,指导药物设计.

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