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Updated: Jul 8, 2026

Purification of Hsp104, a Protein Disaggregase
07:17

Purification of Hsp104, a Protein Disaggregase

Published on: September 30, 2011

协调激活Hsp70伴侣体的激活

Gregor J Steel1, Donna M Fullerton, John R Tyson

  • 1School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.

Science (New York, N.Y.)
|January 6, 2004
PubMed
概括

热冲击蛋白70 (Hsp70s) Lhs1p和Kar2p协调了酵母体内质网膜蛋白质生物生成中的活动. 它们的合ATPase活动,相互调节,对于细胞功能至关重要.

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相关概念视频

Energy to Drive Translocation01:37

Energy to Drive Translocation

Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...