相关实验视频
Updated: Jul 7, 2026
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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
正式合成的 (-) - 甲胺A
Barry M Trost1, Hanbiao Yang, Gary D Probst
1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
Journal of the American Chemical Society
|January 8, 2004
概括
研究人员开发了一种有效的合成策略,用于 (-) - 甲胺A,一个复杂的分子. 关键步骤涉及区域选择性合和散列选择性循环,用于构建核心结构.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 药用化学 医学化学
背景情况:
- (-) - 胺甲是具有潜在生物活性的复杂天然产品.
- 复杂分子的高效和立体选择性合成是有机化学的一个重大挑战.
研究的目的:
- 开发新和高效的策略,以正式合成 (-) - 胺甲基.
- 建立控制复杂分子合成中的立体化学的关键反应.
主要方法:
- 使用Ru-催化基-基合的左侧 (-) -7-基基酸的合成.
- 通过两个连续的Pd(0) -催化O-pi-基循环,构建三氧代卡林核.
- 通过一种新的方法,在C(7) 位置实现了立体化学控制.
主要成果:
- 采用了高度区域选择的Ru-催化基-基合反应.
- 使用了两种Pd(0) 催化O-pi-基循环,一种是化学选择性的,一种是高度选择性的.
- 实现了关键碎片的合成和核心结构的构建.
结论:
- 开发的策略为 (-) - 胺甲基的正式合成提供了一条有效的途径.
- 该研究强调了控制具有挑战性的立体中心和构建复杂分子架构的新方法.
- 进一步的步骤概述了 (-) - 胺甲基的完整的总合成.
相关概念视频
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01:15Carboxylic Acid Derivatives: Overview
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The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
01:11Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
Naming Amides
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