绝经后荷尔蒙治疗的全国使用:年度趋势和对最近证据的反应
Adam L Hersh1, Marcia L Stefanick, Randall S Stafford
1Stanford Prevention Research Center, Program on Prevention Outcomes and Practices, Stanford University School of Medicine, Stanford, Calif 94305, USA.
JAMA
|January 8, 2004
概括
在2002年试验结果揭示了风险后,绝经后荷尔蒙疗法的使用急剧下降. 处方显著下降,许多妇女停止或减少激素治疗 (HT) 剂量.
科学领域:
- 生殖医学 生殖医学
- 临床药理学 临床药理学
- 公共卫生趋势 公共卫生趋势
背景情况:
- 绝经后激素治疗 (HT) 的使用因感知到的健康益处而激增.
- 2002年的试验数据揭示了与口服雌激素/孕激素HT相关的心血管和其他风险.
研究的目的:
- 从1995年到2003年7月,分析荷尔蒙疗法 (HT) 使用的国家趋势.
- 评估新证据对HT处方模式的影响.
主要方法:
- 利用了国家处方审计和国家疾病和治疗指数数据库.
- 从1995年1月到2003年7月,追踪了每年的HT处方和医生处方访问.
主要成果:
- 1999年HT处方达到峰值,直到2002年中期保持稳定.
- 在2002年7月之后,口服雌激素/孕激素组合 (如Prempro) 的处方显著下降 (66%).
- 预计2003年的处方数量接近1995年的水平,这表明临床实践正在迅速转变.
结论:
- 临床实践表明,他们迅速适应了关于HT风险的新证据.
- 自2002年中期以来,大量患者已经停止或减少了激素治疗剂量.
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