民族化需要通过基因组甲基化对FLC进行表观遗传沉默
Ruth Bastow1, Joshua S Mylne, Clare Lister
1Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK.
Nature
|January 9, 2004
概括
植物使用基质子代码来记住冬天,加速开花. 维纳化 (VRN) 基因通过在FLC位点修改组素甲基化来维持这种表观遗传记忆.
科学领域:
- 植物生物学 植物生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子遗传学 分子遗传学
背景情况:
- 许多植物的开花是由冷暴露 (春化) 引发的,以确保有利的条件.
- 在阿拉比多普西斯 (Arabidopsis) 中,本地化通过降低FLC蛋白的调节来加速开花.
- VERNALIZATION (VRN) 基因通过随后的发展保持了减少的FLC表达和感冒的表观遗传记忆.
研究的目的:
- 为了研究在阿拉比多普西斯冬季的表观遗传记忆背后的分子机制.
- 确定VRN1和VRN2在维尔纳化过程中在FLC位点中调解基因组修饰的作用.
主要方法:
- 在野生类型和突变的阿拉比多普西斯植物中,在FLC位点对基因组甲基化模式的分析.
- 研究VRN1和VRN2在维持沉默的染色质状态中的功能.
主要成果:
- 在FLC位点上,Vernalization诱导了组织素H3甲基化 (lysines 9和27的二甲基化) 的特定变化.
- H3 K27二甲基化取决于VRN2,而H3 K9二甲基化需要VRN1和VRN2.
- 这些组织蛋白修饰在动物的沉默染色质状态中被保存.
结论:
- 阿拉比多普西斯冬季的表观遗传记忆是由一个保存的"基因组码"介导的.
- 这种基因组码指定了FLC位置的静态色素状态,确保在暴露于寒冷后加速开花.
- VRN1和VRN2在建立和维护这种表观遗传记忆方面发挥着不同的但协调的作用.
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