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洞察G[bond]T不匹配的识别使用分子动力学与时间平均限制从NMR光谱学衍生的NMR光谱学

Richard J Isaacs1, H Peter Spielmann

  • 1Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536-0084, USA.

Journal of the American Chemical Society
|January 15, 2004
PubMed
概括

分子动力学模拟显示,与正常DNA相比,G[键]T不匹配的DNA表现出明显的动态差异. 这些灵活性变化可能对像MutS.这样的蛋白质对不匹配的识别至关重要.

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