在治疗急性淋巴细胞白血病的儿童中,胰腺β细胞功能受损的持续性
Angelika Mohn1, Alessandro Di Marzio, Rita Capanna
1Department of Paediatrics, University of Chieti, Via Dei Vestini 15, 66100, Chieti, Italy. amohn@unich.it
Lancet (London, England)
|January 17, 2004
概括
治疗急性淋巴细胞白血病 (ALL) 的化疗可以损害胰腺β细胞功能,导致胰岛素反应受损和儿童的葡萄糖不耐受,即使在治疗结束后数年.
科学领域:
- 内分泌学 在内分泌学.
- 儿科瘤学 儿科瘤学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 急性淋巴细胞白血病 (ALL) 治疗可能会影响葡萄糖代谢.
- 在所有幸存者的葡萄糖代谢的长期数据是有限的.
研究的目的:
- 为了研究至少一年的ALL非治疗儿童的葡萄糖代谢.
- 评估ALL治疗对胰岛素反应和葡萄糖耐受性的长期影响.
主要方法:
- 进行了静脉和口服葡萄糖耐受性测试.
- 研究了32名接受ALL治疗且至少1年没有接受治疗的儿童.
主要成果:
- 69%的儿童表现出第一阶段胰岛素反应受损.
- 九个孩子的葡萄糖耐受性受损,一个患有糖尿病.
- 观察到禁食胰岛素,胰岛素生成指数和β细胞功能的降低.
结论:
- 对ALL的化疗与持续的β细胞损伤有关.
- 葡萄糖代谢受损可能是ALL治疗的长期后果.
相关概念视频
Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...


