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乌比基因酶SCFFbw7对抗了阿波性JNK信号传递

Abdolrahman S Nateri1, Lluís Riera-Sans, Clive Da Costa

  • 1Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Science (New York, N.Y.)
|January 24, 2004
PubMed
概括

E3结合酶SCF (Fbw7) 控制了c-Jun的稳定性,防止了神经毒性. 通过降解化c-Jun,SCF(Fbw7) 保护神经元免受Jun N-终端激酶 (JNK) 诱导的亡.

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