汉考克猪膜异体移植的超结构. 植入前和植入后的变化
V J Ferrans1, T L Spray, M E Billingham
1Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20014, USA.
Circulation
|September 1, 1978
概括
葡萄糖甲处理的猪异体移植物因原体分解而随着时间的推移而降解. 本研究检查了植入猪门的结构变化,以了解它们的长期耐用性.
科学领域:
- 生物材料科学 生物材料科学
- 心血管研究研究心血管研究
- 组织工程是组织工程.
背景情况:
- 猪膜异体移植在心脏手术中使用.
- 了解它们的长期结构完整性对于患者的治疗结果至关重要.
研究的目的:
- 为了研究植入后用甲处理的猪膜异体移植的结构变化.
- 确定影响这些生物假体门长期耐用性的因素.
主要方法:
- 使用扫描和传输电子显微镜.
- 研究了植入的猪门 (2天至76个月),未植入的加工门和未加工门.
主要成果:
- 植入的门显示了血蛋白质浸泡,红细胞透,纤维素形成和细胞沉积在2个月内.
- 长期植入 (>2个月) 显示了原干扰,表面侵蚀,血小板聚合和脂质积累.
- 膜表面没有重新内皮质化或形成纤维.
结论:
- 进步的原分解是甲酸处理的猪膜异体移植的长期耐用性的一个关键因素.
- 观察到的结构变化表明这些生物假体器件的长期性能存在局限性.
相关概念视频
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02:18Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.