在患有额头回的患者中,在额头置换期间,尼特罗普鲁塞德对系统和肺部的影响
D G Lappas1, M Ohtaka, N R Fahmy
1Cardiac Anesthesia Group, Department of Anesthesia, Anaesthesia Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Circulation
|September 1, 1978
概括
在门置换过程中,酸在严重的额头肌吐 (MR) 患者中改善了心脏功能. 该药物增加了中风体积,并降低了填充压力和血管阻力,使两个心室受益.
科学领域:
- 心血管医学 心血管医学
- 心脏外科手术 心脏外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 在心脏外科手术中,严重的腹 (MR) 带来了重大挑战.
- 了解血液动力学管理对于接受米特拉置换的患者至关重要.
研究的目的:
- 为了评估酸对严重的MR患者在中枢置换期间系统和肺循环的影响.
- 评估尼特罗普鲁西德对心室功能和血管抵抗的影响.
主要方法:
- 十七名患有严重MR的患者接受了 mitra 门置换.
- 酸尼特罗普鲁塞德在10-65微克/分钟的输液速率下进行了手术.
- 血液动力学参数包括中风体积,填充压力和血管阻力被监测.
主要成果:
- 酸增加了前进冲击体积 (34至46毫升),并降低了左心室填充压力 (28.7至20.6毫米升).
- 系统性血管阻力从2379降至1646dynes.sec.cm-5,肺血管阻力从414降至208dynes.sec.cm-5.
- 观察到平均动脉压的显著降低,平均肺动脉压,以及肺毛细血管压的峰值V波.
结论:
- 谨慎地在手术内使用酸,可以在重症MR患者中改善右心室和左心室的功能,这些患者正在接受中枢置换.
- 这种药物有效地增加了前进冲击体积,同时减少了前负荷和后负荷.
- 酸是这种患者群体中血液动力学管理的宝贵工具.
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