在缺血后再注射期间服用对心肌收缩性,硬度,胀和超结构的影响
T J Bixler1, J T Flaherty, T J Gardner
1Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Circulation
|September 1, 1978
概括
在心脏骤停后服用可以改善心脏功能,减少胀,而不会造成进一步的损伤. 这一发现对于理解在再输血治疗期间肌肉心细胞的保护至关重要.
科学领域:
- 心脏病学 心脏病学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 目前正在研究在缺血和再输后心肌细胞损伤中的作用.
- 低温性缺血性停止可以导致心脏功能受损和细胞损伤.
研究的目的:
- 为了研究管理对心肌收缩性和损伤的作用,在低温缺血性停止和再注射后.
- 评估的潜力,以减轻心脏手术中使用的酸盐基溶液的负面影响.
主要方法:
- 使用在现场输血的异体性犬心制剂 (n=26).
- 将狗分为四组:正常血控制,化 (CaCl2) 给药,酸-乳糖 (CPD) 给药,以及联合CPD和CaCl2给药.
- 评估左心室收缩,心肌硬,细胞/亚细胞损伤和心肌胀后再输血.
主要成果:
- 与对照组 (I组) 相比,的管理 (II组) 改善了左心室收缩性和增加了心肌硬度,而不会导致额外的细胞损伤 (I组).
- 酸盐 (CPD) 管理 (III 组) 减少了收缩性和增加了心肌胀.
- 结合和酸盐的管理 (第四组) 逆转了酸盐诱导的收缩性抑郁症,最小化了胀和增加了性,没有额外的形态损伤.
结论:
- 在再注射15分钟后给药的改善了低温缺血性停止后的心脏收缩性.
- 的管理可以抵消酸盐的负面影响,在心脏护理方面提供潜在的好处.
- 似乎是一种安全的治疗剂,可以改善心脏功能,而不会加剧心肌损伤.
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