烧伤后皮肤中维生素D的合成
Gordon L Klein1, Tai C Chen, Michael F Holick
1Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555-0352, USA. gklein@utmb.edu
Lancet (London, England)
|January 31, 2004
概括
严重的烧伤伤害可能导致儿童维生素D缺乏,影响骨健康. 建议服用维生素D补充剂,以解决烧伤恢复后的这些缺陷.
科学领域:
- 生物化学 生物化学
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
背景情况:
- 严重的烧伤伤害与维生素D缺乏,骨循环受损和不平衡有关.
- 目前的临床实践并没有定期为烧伤患者提供维生素D补充剂或控制阳光照射.
研究的目的:
- 研究严重烧伤后儿童皮肤中维生素D前体转化.
- 评估儿童烧伤幸存者的血清25-氧维生素D水平.
主要方法:
- 对皮肤活检样本进行维生素D3前体的分析.
- 测量紫外线B光照射对7-脱胆固醇转化为维生素D3的影响.
- 血清25-氧维生素D度的量化.
主要成果:
- 在儿童中观察到,7-脱胆固醇转化为维生素D3的转化显著减少,平均在烧后14个月.
- 在研究群体中检测到低血清25-氧维生素D度.
结论:
- 在儿童中,严重烧伤后,皮肤中维生素D前体的转化受损.
- 维生素D缺乏是儿童烧伤幸存者的持续问题.
- 常规维生素D补充剂适用于从严重烧伤中恢复过来的儿童.
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