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用或不使用abciximab治疗的糖尿病患者内腔增生症的体积分析:糖尿病abciximab steNT评估 (DANTE) 随机试验的结果.

Aurea J Chaves1, Amanda G M R Sousa, Luiz A Mattos

  • 1Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.

Circulation
|February 6, 2004
PubMed
概括

在接受冠状动脉支架植入的糖尿病患者中,abciximab并没有减少支架内内膜增生症. 这项研究发现,在两组之间,增生症,复原症或主要心脏不良事件之间没有显著差异.

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科学领域:

  • 心脏病学 心脏病学
  • 干预心脏病学 干预心脏病学
  • 糖尿病并发症 糖尿病并发症

背景情况:

  • 在EPISTENT试验期间,abciximab在糖尿病患者中显著降低了目标血管重血管化.
  • 该机制,特别是抑制内脏增生和复原,需要进一步研究.

研究的目的:

  • 为了评估abciximab对2型糖尿病患者冠状动脉支架植入后的内脏增生症的影响.
  • 评估阿布西西马布是否能降低内脏增多,复原率和主要心脏不良事件.

主要方法:

  • 一项随机试验,涉及96名糖尿病患者 (96个病变) 接受选择性支架植入.
  • 患者被分配给接受abciximab或没有abciximab.
  • 血管内超声波用于测量在6个月的随访时的静脉内膜增生体积.

主要成果:

  • 在abciximab组 (41.3+/-21.0%) 和对照组 (40.5+/-18.3%) 之间,静脉内膜增生体积没有显著差异.
  • 血管检查结果,包括最小的光径,晚期损失和恢复率在各组之间相似.
  • 在12个月内,主要心脏不良事件的累积发病率也是可比的.

结论:

  • 在冠状动脉支架植入期间使用abciximab并不能减少糖尿病患者的支架内膜增生症.
  • 这种药物在这个患者群体中没有影响缩率或其他不良心脏事件.