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在VKORC1中发生的突变会导致华法林耐药性和多重凝血因子缺陷2型

Simone Rost1, Andreas Fregin, Vytautas Ivaskevicius

  • 1Department of Human Genetics, University of Würzburg, Biozentrum, Am Hubland, 97074 Würzburg, Germany.

Nature
|February 7, 2004
PubMed
概括

研究人员确定了维生素K环氧化减少酶复合体子单元1 (VKORC1) 基因,该基因对血液凝结和华法林药物功能至关重要. 在VKORC1突变与出血障碍和华法林耐药性有关.

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