肥胖对血 natriuretic水平的影响
Thomas J Wang1, Martin G Larson, Daniel Levy
1Framingham Heart Study, Framingham, Mass 01702, USA.
Circulation
|February 11, 2004
概括
肥胖个体表现出较低水平的尿素,这是平衡和血压的关键调节者. 这些降低的水平可能会增加患高血压和相关疾病的风险.
科学领域:
- 心血管科学 心血管科学
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖与高血压有关,而保留和交感过度活跃是潜在的机制.
- 尿素调节平衡和神经激素平衡,这表明它在与肥胖有关的高血压中起作用.
- 假设肥胖症中的 natriuretic 的反应受损.
研究的目的:
- 调查肥胖与B型性尿素 (BNP) 和N终端亲子性尿素 (N-ANP) 的循环水平之间的关系.
- 为了确定肥胖是否与降低的酸水平有关,可能导致高血压风险.
主要方法:
- 在3389名没有心力衰竭的Framingham研究参与者中分析了血BNP和N-ANP水平.
- 多变量回归分析调整了临床和心声学因素.
- 基于测试检测极限和性别特异性四分位数的低尿酸水平的分类.
主要成果:
- 与瘦个体相比,肥胖男性和女性的血BNP和N-ANP水平明显较低 (男性趋势P<0.0001,女性趋势P<0.001).
- 与瘦个体相比,肥胖个体具有较低血BNP和N-ANP的几率明显更高.
- 糖尿病也与低尿酸水平有关,与肥胖相结合时具有附加的负面影响.
结论:
- 肥胖与 natriuretic 的循环水平降低有关.
- 肥胖个体的低尿素水平可能会导致他们对高血压的敏感性增加.
- 这些发现突出了一个潜在的机制,将肥胖与高血压和相关疾病联系在一起.
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