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通过定向进化扩大DNA聚合酶的基质谱

Ming Fa1, Annalisa Radeghieri, Allison A Henry

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037-1000, USA.

Journal of the American Chemical Society
|February 12, 2004
PubMed
概括

研究人员设计了新的核酸聚合酶,能够合成非自然的2'-O-甲基聚合物. 这一突破通过克服现有酶的基质特异性限制,扩大了生物技术和治疗应用.

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