在治疗多药耐药结核病的方案和原则
Joia S Mukherjee1, Michael L Rich, Adrienne R Socci
1Brigham and Women's Hospital, Division of Social Medicine and Health Inequalities, Boston, MA, USA. jmukherjee@pih.org
Lancet (London, England)
|February 14, 2004
概括
多药耐药结核病 (MDR-TB) 治疗在资源乏的环境中是可行的. 早期,高剂量二线药物的积极治疗和坚持策略对于管理MDR-TB至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- 耐多药结核病 (MDR-TB) 构成了全球重大卫生挑战.
- 针对MDR-TB的有效管理策略仍在发展,特别是在资源有限的环境中.
研究的目的:
- 审查有关MDR-TB治疗的现有科学文献.
- 确定关键的见解和建议,以管理资源贫乏的环境中MDR-TB.
主要方法:
- 对MDR-TB治疗的回顾性队列研究的系统审查.
- 分析治疗方案,剂量,坚持策略和可用的融资机制.
主要成果:
- 在资源贫困的环境中,MDR-TB治疗是可以实现的.
- 建议早期干预,积极的治疗方案,二线药物的高端剂量和直接观察治疗.
- 全球基金和绿灯委员会等全球性倡议促进了获得治疗的机会.
结论:
- 在发展中国家,MDR-TB的管理越来越有可能.
- 为了优化MDR-TB治疗指南,进一步的临床和操作研究是必不可少的.
- 可访问的MDR-TB治疗在最需要的地区至关重要.
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