大动脉根运动在大动脉剖析病变发生过程中的作用
Carsten J Beller1, Michel R Labrosse, Mano J Thubrikar
1Clinic for Cardiothoracic Surgery, Heart Institute Lahr/Baden, Germany.
Circulation
|February 19, 2004
概括
大动脉根的运动和高血压显著增加了上升大动脉的压力. 对高血压患者来说,监测大动脉根位移对于有大动脉剖析风险的高血压患者来说至关重要.
科学领域:
- 心血管力学心血管力学
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 大动脉根在心脏周期中的向下运动是大动脉剖析中撕裂的潜在原因.
- 了解大动脉根的生物力学对于诊断和管理大动脉剖析至关重要.
研究的目的:
- 用有限元模型评估大动脉根位移和压力对大动脉壁应力的影响.
- 调查大动脉根运动,高血压和大动脉剖析风险之间的关系.
主要方法:
- 在40名心脏病患者中进行了对比注射.
- 开发出了大动脉根,门和分支的有限元素模型.
- 测量了大动脉根轴位移,并与患者的疾病相关联,如大动脉功能不充分和左心室低动.
主要成果:
- 大动脉根轴位移范围从0到14毫米,根据大动脉缺陷和左心室低运动等情况而有所不同.
- 纵向应力最大的增加 (50%) 发生在大约2厘米以上的 sino-tubular 结与8.9毫米的轴位移和120毫米压.
- 在没有轴位移的情况下增加光压到180mmHg时,产生了类似的应力增加.
结论:
- 大动脉根位移和高血压都显著提高了上升大动脉的纵向应力.
- 应该监测大动脉根运动作为一个关键的风险因素在高血压患者易受大动脉剖析.
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