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皮塔瓦斯塔丁降低了巨细胞B型清理受体CD36的表达

Jihong Han¹, Xiaoye Zhou, Toru Yokoyama

¹Center of Vascular Biology and Department of Pathology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA.

|February 19, 2004

概括

皮塔瓦斯塔丁通过抑制CD36表达来减少巨细胞对氧化LDL的吸收. 这表明皮塔瓦斯塔丁可以防止动脉样硬化中的泡细胞形成.

科学领域:

心血管研究研究心血管研究
分子生物学分子生物学
药理学药理学是一个学科.

背景情况:

皮塔瓦斯塔丁是一种新型的HMG-CoA减少酶抑制剂,用于降低胆固醇.
在巨细胞中氧化的LDL积累是动脉样硬化中泡细胞形成的关键.
CD36拾尸体受体在氧化LDL吸收中发挥着关键作用.

研究的目的:

为了研究皮塔瓦斯塔丁对巨细胞中CD36表达的作用.
确定皮塔瓦斯塔丁影响CD36表达的机制.
探索皮塔瓦斯塔丁对氧化LDL吸收和泡细胞形成的影响.

主要方法:

用皮塔瓦斯塔丁对J774细胞和小鼠巨细胞进行剂量依赖的治疗.
在各种细胞类型中分析CD36mRNA和蛋白质表达.
调查皮塔瓦斯塔丁对增殖器激活受体- (PPARgamma) 和MAPK信号通路的影响.

主要成果:

皮塔瓦斯塔丁显著降低了巨细胞中的CD36mRNA和蛋白质表达.
皮塔瓦斯塔丁降低了氧化LDL的结合和巨细胞的吸收.
皮塔瓦斯塔丁降低了PPARgamma表达和调节了PPARgamma酸化.

结论:

皮塔瓦斯塔丁抑制了巨细胞的CD36表达,从而阻止了氧化LDL的吸收.
该机制涉及PPARgamma依赖的CD36.6的转录下调.
皮塔瓦斯塔丁在动脉样硬化中显示出调节CD36介导泡细胞形成的潜力.

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