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胡须的运动是通过刺激大鼠运动皮层中单个金字塔细胞引起的

Michael Brecht¹, Miriam Schneider, Bert Sakmann

¹Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany. brecht@mpimf-heidelberg.mpg.de

|February 20, 2004

概括

鼠的运动皮质神经元中的单个动作潜能 (AP) 可以启动胡须运动. 特定的神经元层影响运动节奏,方向和振幅,即使神经元活动稀疏.

科学领域:

神经科学是一个神经科学.
发动机控制器的控制器

背景情况:

运动皮层中的神经元活动与运动相关.
来自皮层神经元的个别动作潜能 (AP) 在产生运动中的确切作用仍然不清楚.

研究的目的:

为了研究单个皮质神经元活动和胡须运动的产生之间的因果关系.
确定不同的神经元层和发射模式如何影响运动特征.

主要方法:

电生理学记录在老鼠运动皮层.
刺激单个金字塔神经元 (第5层和第6层).
观察和分析唤起的胡须运动.

主要成果:

在单个金字塔细胞中的AP列车可以唤起胡须运动的序列.
第5层金字塔细胞可以重置胡须运动节奏.
第6层的金字塔细胞产生节奏的动,具有可变的相位.
APs影响运动发作的延迟,方向和幅度.
唤起的运动是独立于背景皮质活动的,并在清醒时增强.

结论:

振动运动皮层中稀疏的AP活动足以唤起运动.
个体皮层神经元在控制运动产生方面发挥着直接作用.
神经元发射模式编码特定的运动参数.

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