端粒长度和可能与X染色体的联系
Tim S Nawrot1, Jan A Staessen, Jeffrey P Gardner
1Study Coordinating Centre, Laboratory of Hypertension, Department of Molecular and Cardiovascular Research, University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
Lancet (London, England)
|February 21, 2004
概括
端粒长度是细胞衰老的标志物,似乎是以X链的方式遗传的. 这表明,衰老过程本身可能是一个X相关的特征.
科学领域:
- 遗传学 遗传学 是一个
- 人类生物学 人类生物学
- 衰老研究研究 衰老研究
背景情况:
- 端粒长度反映了细胞复制史,并与临床衰老标志物有关.
- 以前的双胞胎研究表明,端粒长度是家族性的,但其遗传模式仍然不清楚.
研究的目的:
- 研究人类端粒长度遗传的模式.
主要方法:
- 终端限制片段 (TRF) 的长度在白细胞的DNA中被测量.
- 数据来自基于家庭的队列 (环境,基因和健康结果的佛兰德研究).
主要成果:
- 在配偶之间或父亲与儿子之间没有发现TRF长度的显著相关性.
- 在父亲和女儿,母亲和孩子以及兄弟姐妹之间观察到TRF长度的强烈相关性.
结论:
- 与X相关的遗传是观察到的端粒长度相关性最可能的解释.
- 这些发现表明,衰老可能是一个与X相关的特征,等待进一步确认.
相关概念视频
Dihybrid Crosses
Overview
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Trihybrid Crosses
Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Incomplete Dominance
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
X and Y Chromosomes
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...


