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较慢的早期生长对长期的心血管健康有益吗?
Atul Singhal1, Tim J Cole, Mary Fewtrell
1MRC Childhood Nutrition Research Center, Institute of Child Health, 30 Guilford St, London, UK, WC1N 1EH. a.singhal@ich.ucl.ac.uk
Circulation
|March 3, 2004
概括
新生儿早期增长加速与晚年心血管健康状况较差有关. 新生儿生长速度较慢,特别是在早产婴儿中,与青春期更好的血管功能有关.
科学领域:
- 新生儿发育的新生儿发展
- 心血管健康的心血管健康
- 血管功能 血管功能
背景情况:
- 动物新生儿加速生长与心血管疾病 (CVD) 风险增加有关.
- 缓慢的早期生长被假设对长期健康有保护作用.
- 这项研究调查了早期生长模式对人类心血管健康的影响.
研究的目的:
- 评估新生儿生长率与青春期内皮功能之间的关系.
- 为了比较早产婴儿的血管功能,与不同的早期生长轨迹和定期出生对照.
主要方法:
- 利用高分辨率的血管超声波来测量青少年 (13-16岁) 的流媒扩张 (FMD).
- 将一个早产婴儿队列 (n=216) 与一个早产对照组 (n=61) 进行比较.
- 分析了腕动脉直径的变化,以应对反应性高血压.
主要成果:
- 在出生后的头两周内,体重增加或线性增长与青春期的口炎显著降低有关.
- 早期生长率最低的青少年 (预产期组) 与早期生长率最高的青少年和预产期对照人群相比,表现出更高的口炎.
- 早期增长加速对口病的负面影响很大,与吸烟等成年风险因素相美.
结论:
- 新生儿加速生长会对长期的心血管健康产生负面影响,特别是内皮功能.
- 产后生长速度较慢,特别是在早产儿中,与青春期血管健康的改善有关.
- 早期生长模式可以解释出生体重与晚期心血管疾病风险之间的联系.
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