的 (+) -SCH 351448 的总合成
Eun Joo Kang1, Eun Jin Cho, Young Eun Lee
1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-747, Korea.
Journal of the American Chemical Society
|March 5, 2004
概括
通过环闭式氨酸转化合成SCH 351448的总合成. 这种方法有效地准备了复杂的28个成员的宏二氧化物结构.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 药用化学 医学化学
背景情况:
- SCH 351448是一种具有潜在生物活性的复杂宏二醇.
- 有效的合成途径对于获取这些分子进行进一步研究至关重要.
研究的目的:
- 为了实现SCH 351448.8.的总合成.
- 开发一个可扩展和高效的合成战略,用于macrodiolides.
主要方法:
- 这项研究采用了环闭氨酸转化反应 (RCM) 的战略应用.
- 关键步骤包括构建适应RCM的宏循环前体.
主要成果:
- 成功完成了SCH 351448的总合成.
- 环关闭的烯转化反应证明是有效的,用于构建28个成员的宏二氧化环系统.
结论:
- 开发的合成途径为生产SCH 351448.8提供了一种可行的方法.
- 这一综合强调了RCM在构建复杂的宏环自然产品中的实用性.
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