Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Replication in Prokaryotes02:35

Replication in Prokaryotes

Overview
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Ancient DNA reveals pervasive directional selection across West Eurasia.

Nature·2026
Same author

Functional dissection of complex trait variants at single-nucleotide resolution.

Nature·2026
Same author

Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Rewriting regulatory DNA to dissect and reprogram gene expression.

Cell·2025
Same author

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes.

Science (New York, N.Y.)·2025
Same author

A standing platform for cancer drug development using ctDNA-based evidence of recurrence.

Nature reviews. Cancer·2024

相关实验视频

Updated: May 11, 2026

BEST: Barcode Enabled Sequencing of Tetrads
12:59

BEST: Barcode Enabled Sequencing of Tetrads

Published on: May 1, 2014

在酵母菌Saccharomyces cerevisiae中古代基因组复制的证据和进化分析.

Manolis Kellis1, Bruce W Birren, Eric S Lander

  • 1The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02138, USA. manoli@mit.edu

Nature
|March 9, 2004
PubMed
概括
此摘要是机器生成的。

酵母菌Saccharomyces cerevisiae是从一个全基因组重复事件进化而来的. 分析相关的酵母物种揭示了基因重复和损失塑造了它的基因组,使进化创新的研究成为可能.

更多相关视频

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

Determination of S-Phase Duration Using 5-Ethynyl-2'-deoxyuridine Incorporation in Saccharomyces cerevisiae
08:40

Determination of S-Phase Duration Using 5-Ethynyl-2'-deoxyuridine Incorporation in Saccharomyces cerevisiae

Published on: October 21, 2022

相关实验视频

Last Updated: May 11, 2026

BEST: Barcode Enabled Sequencing of Tetrads
12:59

BEST: Barcode Enabled Sequencing of Tetrads

Published on: May 1, 2014

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

Determination of S-Phase Duration Using 5-Ethynyl-2'-deoxyuridine Incorporation in Saccharomyces cerevisiae
08:40

Determination of S-Phase Duration Using 5-Ethynyl-2'-deoxyuridine Incorporation in Saccharomyces cerevisiae

Published on: October 21, 2022

科学领域:

  • 进化生物学是进化的生物学.
  • 基因组学就是基因组学.
  • 酵母遗传学 酵母遗传学

背景情况:

  • 整个基因组复制 (WGD) 是进化创新的推动力.
  • 在Saccharomyces cerevisiae中寻找古代WGD的证据已经通过比较基因组学.

研究的目的:

  • 为了研究Saccharomyces cerevisiae的进化历史.
  • 为了证实或驳斥在酵母中古代全基因组复制事件的假设.
  • 分析复制基因在WGD后的命运和功能.

主要方法:

  • 对Saccharomyces cerevisiae和Kluyveromyces waltii进行比较基因组学分析.
  • 基因组测序的Kluyveromyces waltii. 这是一个.
  • 鉴定基因重复和损失模式.

主要成果:

  • 证据表明K. waltii和S. cerevisiae之间的1:2基因组映射,支持古代WGD.
  • 证实Saccharomyces cerevisiae起源于一个全基因组重复事件.
  • 观察到95%的加速进化病例只涉及复制对中的一个基因.

结论:

  • 全基因组重复是Saccharomyces cerevisiae的进化的一个重要因素.
  • 在WGD之后的基因损失和专业化有助于进化创新.
  • 这项研究为区分祖先和衍生基因功能提供了一个框架.