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Updated: May 6, 2026

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从沉默到基因表达:单细胞实时分析

Susan M Janicki1, Toshiro Tsukamoto, Simone E Salghetti

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Cell
|March 10, 2004
PubMed
概括

研究人员创建了一个新的系统,可以实时跟踪基因表达,从DNA到蛋白质. 这一突破揭示了染色质结构的变化如何驱动基因激活,为基因表达提供了动态视图.

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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