接种流感疫苗后多次错误阳性艾滋病毒,HTLV-1和C型肝炎血清测试,1991年
W R Mac Kenzie1, J P Davis, D E Peterson
1Bureau of Public Health, Wisconsin Division of Health, Madison 53703.
JAMA
|August 26, 1992
概括
流感疫苗接种与献血者多次假阳性病毒查测试有关. 这种暂时的问题,主要是针对HIV和HTLV-1,是不常见的,并会消失,这表明接种疫苗的人不需要推迟接种.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 献血查依赖于敏感的病毒酶相关免疫吸收试验 (ELISA) 来检测HIV,HTLV-1和HCV等感染.
- 假阳性结果可能导致捐赠者延期,并影响血液供应.
- 了解导致错误阳性结果的因素对于血液安全和捐赠者管理至关重要.
研究的目的:
- 在献血者中识别与多次假阳性病毒ELISA相关的因素.
- 为了确定这个现象的频率和时间特征.
主要方法:
- 在区域血液中心进行了一项病例控制研究.
- 病例捐赠者有多次假阳性病毒ELISA;对照捐赠者是血清阴性.
- 对捐赠记录进行了审查,以查看流感疫苗接种情况和时间.
主要成果:
- 在17941名捐赠者中,确定了10名病例捐赠者.
- 10名病例捐赠者中有9人接种了流感疫苗,而30名对照组中有3人 (OR=81,P<.001).
- 在接种疫苗后52-130天内解决了对HIV/HTLV-1的错误阳性;HCVELISA在4/7例中持续存在.
结论:
- 献血者多次假阳性病毒ELISA与流感疫苗接种有关.
- 这种现象对于HIV/HTLV-1来说是罕见的,短暂的,对于HCV来说可能会持续更长时间.
- 流感疫苗接种不应推迟;假阳性捐赠者可能会重新考虑未来的捐赠.
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