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关于吸烟和男性白内障风险的前性研究
W G Christen1, J E Manson, J M Seddon
1Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02215.
JAMA
|August 26, 1992
概括
吸烟显著增加了发展核硬化和后部亚囊性白内障的风险. 沉重吸烟者 (每天20支以上的香烟) 面临的风险最高,而过去吸烟者显示后部亚囊性白内障的潜在风险增加.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,白内障是导致视力障碍的主要原因.
- 生活方式因素,特别是吸烟在白内障发展中的作用需要进一步阐明.
研究的目的:
- 调查吸烟与与年龄相关的白内障发生率之间的联系.
- 为了确定吸烟是否影响特定类型的白内障,即核硬化和后部亚囊白内障.
主要方法:
- 使用来自医生健康研究 (N=17,824名男性医生) 的数据进行的前性队列研究.
- 评估了基线吸烟状态 (当前,过去,从未吸烟).
- 发生白内障的诊断通过医疗记录审查在60个月的随访中得到证实.
主要成果:
- 目前每天吸20支或更多支烟的人患白内障的风险显著增加 (RR,2.05).
- 沉重的吸烟与核硬化症 (RR,2.24) 和后部亚囊性白内障 (RR,3.17) 的风险增加有关.
- 过去的吸烟者表现出一种趋势,即背部亚囊性白内障的风险增加 (RR,1.44;P=.07).
结论:
- 吸烟是发展核硬化和后部亚囊性白内障的重要危险因素.
- 这些发现支持吸烟有助于白内障发生的假设.
- 公共卫生倡议应强调戒烟,以减少白内障负担.
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