核激素受体中的Allostery和合序列变异
1Howard Hughes Medical Institute, Departments of Molecular and Cell Biology and of Chemistry, University of California, Berkeley, CA 94707, USA.
Cell
|March 16, 2004
概括
分析相关蛋白质的序列变异揭示了全联结机制. 核激素受体的突变证实了这些发现,影响了RXR异构体中的配体反应.
科学领域:
- 分子生物学分子生物学
- 生物化学 生物化学
- 进化生物学 进化生物学
背景情况:
- 相关序列变异分析提供了关于蛋白质功能位点之间的全结合的见解.
- 核激素受体是研究这些机制的关键蛋白质家族.
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