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强力光谱监测单个蛋白质的折叠轨迹

Julio M Fernandez1, Hongbin Li

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027, USA. jfernandez@columbia.edu

Science (New York, N.Y.)
|March 16, 2004
PubMed
概括

单分子力原子力显微镜观察到无处不在的蛋白质折叠. 折叠时间取决于蛋白质的长度和施加的力,显示出不同的折叠阶段和波动.

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Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...