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相关概念视频

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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骨髓衍生干细胞的局部输送通过膜机制增加了附带 perfusion.

T Kinnaird1, E Stabile, M S Burnett

  • 1Cardiovascular Research Institute, Washington, DC 20010, USA. tim.kinnaird@medstar.net

Circulation
|March 17, 2004
PubMed
概括
此摘要是机器生成的。

介质干细胞 (MSCs) 通过分泌的因素促进血管生长,而不是细胞结合. 这种对膜效应在小鼠的动脉绑定后改善了四肢 perfusion 和功能.

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科学领域:

  • 再生医学是一种再生医学.
  • 血管生物学 血管生物学
  • 细胞疗法细胞疗法

背景情况:

  • 已知骨髓细胞疗法可通过细胞集成帮助形成附带细胞.
  • 骨髓细胞对这一过程的副质 (分泌因子) 贡献不太清楚.

研究的目的:

  • 为了研究由骨髓衍生的树皮细胞 (MSCs) 所分泌的副因子在附带重塑中的作用.
  • 为了确定MSC是否通过分泌因素或直接纳入,有助于血管修复.

主要方法:

  • 培养了来自小鼠骨髓的树皮细胞 (MSC),并对其条件介质 (MSC-CM) 进行了生长因子分析.
  • 在实验室中测试了MSC-CM对内皮细胞和光滑肌肉细胞增殖的影响.
  • 在关节动脉绑定的小鼠中进行了MSC注射,并评估了四肢 perfusion,血管形成和组织健康.
  • 在体内追踪标记的MSC和测量局部生长因子水平进行了.

主要成果:

  • MSCs释放血管内皮生长因子 (VEGF),基本纤维细胞生长因子 (bFGF) 和其他细胞因子.
  • MSC-CM促进了内皮和光滑肌肉细胞的增殖,部分是通过VEGF和FGF.
  • 在小鼠中注射MSC改善了四肢 perfusion,增加了导电性血管,增强了四肢功能,并减少了组织损伤,而无需将MSC纳入新血管.
  • 多重体细胞增加了局部VEGF和bFGF水平,VEGF与移植细胞同位.

结论:

  • MSCs分泌许多动脉致动细胞因子,刺激血管生长.
  • 主要通过膜机制,MSCs促进了附带重塑并改善了四肢 perfusion.