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Updated: Jul 8, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

一种高度强效和选择性的PKCalpha抑制剂,通过对基架的组合修改生成

Jung Hwan Lee1, Sandip K Nandy, David S Lawrence

  • 1The Albert Einstein College of Medicine, Department of Biochemistry, 1300 Morris Park Ave., Bronx, New York 10461, USA.

Journal of the American Chemical Society
|March 18, 2004
PubMed
概括

研究人员开发了一种强大且有选择性的蛋白激酶Cαα (PKCα) 抑制剂. 这种新型的抑制剂显示出高的疗效和特异性,为生物化学研究提供了宝贵的工具.

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Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...