聚聚合物混合物的固相ATRP合成
Ying Mei1, Kathryn L Beers, H C Michelle Byrd
1Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.
Journal of the American Chemical Society
|March 18, 2004
概括
研究人员开发了一种新方法,利用从固体支的基中使用原子转移激素聚合 (ATRP) 来创建混合生物材料. 这种技术成功合成了GRGDS功能化的聚合物,促进了细胞粘附,并使生物材料与细胞相互作用的控制成为可能.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 表面化学 表面化学
背景情况:
- 开发具有受控分子架构的先进生物材料对于调节生物相互作用至关重要.
- 聚合物的体功能化可以赋予特定的生物信号传导能力.
- 固相合成为创建定义良好的聚合物结构提供了优势.
研究的目的:
- 从树脂支持的基中通过原子转移基聚合 (ATRP) 制备混合生物材料的多功能方法.
- 通过这种新的固相方法合成和表征一种GRGDS功能化的聚合物.
- 为了评估合成的酸聚合物合物的细胞粘附性质.
主要方法:
- 原子转移基聚合 (ATRP) 来自树脂支持的.
- 合成GRGDS功能化的多2-基乙基甲酸盐 (PHEMA).
- 使用固态 (13) C NMR 和凝浸透色谱 (GPC) 进行表征.
- 细胞粘附实验,以评估生物活性.
主要成果:
- 成功合成了一种GRGDS功能化的聚合物,其数值平均分子量为4420和聚分散度为1.47.
- 证实ATRP反应从结固体支中有效,具有近量合成.
- 已证明GRGDS序列促进了细胞粘附,与非功能化的PHEMA不同.
- 验证了将细胞信号部分纳入具有定义分子架构的材料的能力.
结论:
- 已经建立了一种多功能固体相方法,用于从树脂支持的酸中使用ATRP制备混合生物材料.
- 合成的GRGDS功能化聚合物有效促进细胞粘附,证明了控制生物材料-细胞相互作用的潜力.
- 这种方法允许精确地将细胞信号部分纳入聚合物材料,为先进的组织工程和再生医学应用铺平了道路.
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