相关实验视频
Updated: Aug 7, 2026

09:27
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
具有效应体表型和控制病毒复制的HIV-1特定CD8+T细胞
Christoph Hess1, Marcus Altfeld, Seddon Y Thomas
1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Harvard Medical School, Massachusetts, USA.
Lancet (London, England)
|March 20, 2004
概括
大多数HIV-1感染者由于CD8+ T细胞未成熟而无法控制病毒. 在控制HIV-1的个体中观察到的这些细胞的完全成熟,可能是控制病毒的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 大多数感染人类免疫缺陷病毒1型 (HIV-1) 的人无法控制病毒复制.
- 病毒特异性CD8+ T细胞的存在并不能保证病毒的控制.
- 缺乏控制的一个潜在原因是CD8+ T细胞未能成熟成为完全分化的效应细胞.
研究的目的:
- 为了研究一种假设,即CD8+ T细胞成熟受损有助于不受控制的HIV-1复制.
- 为了比较病毒特异性CD8+ T细胞在受控和不受控制的HIV-1感染的个体中的成熟状态.
主要方法:
- 在HIV-1感染个体中分析CD8+T细胞成熟表型.
- 在经过治疗的急性感染后接受结构化治疗中断 (STI) 的患者和未经治疗的慢性感染个体与自发病毒控制之间的比较.
- 评估穿孔素表达作为效应细胞功能的标志物.
主要成果:
- 在经过治疗的急性HIV-1感染中,结构化治疗中断 (STI) 导致病毒复制控制,与完全分化病毒特异性CD8+ T细胞的扩张相关.
- 这些效应细胞的类似扩张在未经治疗的个体中观察到,自发的HIV-1控制.
- 在这两组中都发现了增加的穿孔素表达,这表明细胞毒性潜力增强.
结论:
- 病毒特异性CD8+ T细胞的完全成熟甚至可以在HIV-1感染期间实现.
- CD8+ T 细胞成熟成为完全差异化的效应体表型似乎对于实现和维持HIV-1病毒控制至关重要.
相关概念视频
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

