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相关概念视频

What are Proteins?01:55

What are Proteins?

Overview
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...

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相关实验视频

Updated: Jul 20, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
07:54

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

短时间 (+/-) - 石柱蛋白的总合成.

Phil S Baran1, Alexandros L Zografos, Daniel P O'Malley

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. pbaran@scripps.edu

Journal of the American Chemical Society
|March 25, 2004
PubMed
概括

研究人员开发了一条简短的合成路径,以获得新型化学特性和生物活性的分子 - - 子. 这种新方法在没有染色学的情况下实现了24%的总产量,克服了长期存在的合成挑战.

科学领域:

  • 有机化学 有机化学
  • 合成化学 合成化学
  • 自然产品的合成自然产品的合成

背景情况:

  • 石杖是一种海洋天然产品,由于其复杂的结构,它存在重大合成挑战.
  • 自1981年以来,其独特的化学特性和强大的生物活性使其成为总合成的目标.

研究的目的:

  • 开发一个简洁和实用的整体合成的权杖.
  • 为了应对与石章结构相关的化学挑战,并实现高效的合成.

主要方法:

  • 采用了一种新的氧四四旋旋风重排策略.
  • 开发了一种新的化学和区域选择性化方法.
  • 采用一种温和的序列来形成2-aminoimidazole.

主要成果:

  • 在最少的步骤数量中成功合成 (+/-) -ceptrin.
  • 从二甲基乙烯基基碳酸盐获得了24%的总产量.
  • 在没有使用任何染色学净化的情况下完成了合成.

结论:

  • 报告的合成策略为石章蛋白合成提供了一种高效和实用的解决方案.

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Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

Published on: August 6, 2018

  • 这项工作克服了天然产品化学中的突出合成挑战.
  • 开发的方法可能适用于合成相关化合物.