用质谱和巴克明斯特富勒伦探针进行分子特异成像:用于表征固相合成组合图书馆的应用
Jiyun Xu1, Christopher W Szakal, Scott E Martin
1Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Journal of the American Chemical Society
|March 25, 2004
概括
一个新的buckminsterfullerene (C(60) 离子束显著提高了固相合成中的分析. 这项技术能够快速,分子特定的树脂颗粒成像,提高高通量选能力.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 固相合成对于组合图书馆至关重要.
- 在聚合物支上对各种分子进行表征具有分析挑战.
- 传统的原子离子束在分子吸附和成像方面存在局限性.
研究的目的:
- 开发和评估一种新型的buckminsterfullerene (C(60) 主离子束,用于飞行时间的二次离子质谱 (TOF-SIMS).
- 评估C(60) 离子束在合成中对树脂颗粒的分子特异成像的能力.
- 为了比较C(60) 离子束与原子离子束的性能,以增强分子特征.
主要方法:
- 使用一种新开发的C(60) 主离子束TOF-SIMS系统.
- 聚焦C(60) 离子束到1.5微米的点大小,用于高分辨率成像.
- 分析了在聚合物树脂颗粒上合成的小类图书馆.
- 研究了不同基板上的能量消散和电荷积累.
主要成果:
- 与原子离子束相比,分子离子的有用产量提高了>3个数量级.
- 从聚合物表面上有效地脱离小,对更硬的基板的影响降低.
- 观察到绝缘聚合物珠的表面充电显著减少.
- 成功测试了100微米聚合物珠的表面成分,其速度高达10颗/秒.
结论:
- C(60) 主离子束TOF-SIMS是用于快速,分子特定分析库的强大工具.
- 这项技术在灵敏度,效率和高通量查的样品准备减少方面提供了显著的优势.
- 这些发现为在各种基质上表征多样化的分子阵列开辟了新的途径.
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