在中非狩猎者中自然获得的猿类逆转录病毒感染
Nathan D Wolfe1, William M Switzer, Jean K Carr
1Department of Epidemiology Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. nwolfe@jhsph.edu
Lancet (London, England)
|March 27, 2004
概括
复原病毒,如猿类泡病毒 (SFV),正在从非人类灵长类动物积极地穿越到中非的人们身上. 这种动物传播突显了与感染灵长类动物处理相关的风险,并表明减少野肉狩猎可以防止未来的疾病出现.
科学领域:
- 病毒学 病毒学
- 动物传播疾病 动物传播疾病
- 灵长类健康 灵长类健康
背景情况:
- 据信,艾滋病毒大流行源于非人类灵长类动物的猿类免疫缺陷病毒 (SIV).
- 虽然在实验室和动物园环境中已知职业动物性传染性逆转录病毒暴露,但在自然环境中的传播仍然未经记录.
- 这项研究调查了中非人群中动物性逆转录病毒感染的情况.
研究的目的:
- 研究居住在中非森林的人群中动物性反病毒感染的发生和模式.
- 确定涉及人类传播的特定逆转录病毒和非人类灵长类动物来源.
- 评估人类与灵长类动物接触在逆转录病毒疾病出现中的作用.
主要方法:
- 从喀麦隆农村的个人收集行为数据,血样本和外围血液淋巴细胞.
- 血清学测试用于检测抗逆病毒抗体.
- 聚合酶连锁反应 (PCR) 和序列分析以确认和表征复原病毒感染.
主要成果:
- 在报告与野生非人类灵长类动物血液和体液接触的个体中发现了动物性 Simian Foamy Virus (SFV) 感染.
- 在1099名研究人员中,在10名 (1%) 发现了SFV抗体.
- 序列分析揭示了三种截然不同的,地理上独立的人类SFV传输来源于德布拉扎的,和大猩猩.
结论:
- 逆转录病毒从非人类灵长类动物积极传播到中非人类群体,SFV是有记录的例子.
- 与非人类灵长类动物的密切接触,特别是在狩猎和屠宰期间,有助于人类逆转录病毒的出现.
- 减少对灵长类肉的狩猎可能会减少这种动物传染病突发事件的发生率.
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