神经系统疾病中的疲劳.
Abhijit Chaudhuri1, Peter O Behan
1Division of Clinical Neurosciences, University of Glasgow, Glasgow G51 4TF, UK. ac54p@udcf.gla.ac.uk
Lancet (London, England)
|March 27, 2004
概括
慢性疲劳显著影响神经系统疾病,如多发性硬化症. 中心疲劳,其特点是感知力度增加和耐力降低,涉及复杂的大脑通路中断.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 病理生理学 病理生理学
背景情况:
- 慢性疲劳是各种神经系统疾病的普遍和残疾症状,包括多发性硬化症,脊髓灰质炎后,中风后和慢性疲劳综合征.
- 疲劳表现为外周疲劳 (肌肉疲劳) 或中心疲劳,影响身体和精神的耐力.
- 中心疲劳涉及加强对努力的感知和有限的持续活动能力.
研究的目的:
- 阐明神经系统疾病中中枢疲劳背后的病理生理机制.
- 探索下丘脑-垂体-上腺轴在持续性中央疲劳的发展中的作用.
主要方法:
- 审查关于中心疲劳病理生理学的现有文献.
- 对影响神经通路的代谢和结构性病变的分析.
- 检查皮质低血和下丘脑-垂体-上腺轴的敏感性.
主要成果:
- 中央疲劳与破坏连接基底,乳头,边缘系统和皮质中心的通路的病变有关.
- 预先存在的低皮质素血症可能会使个人倾向于持续的中枢疲劳后压力.
- 生理学,认知和情感因素的相互作用对疲劳作出了不同的贡献.
结论:
- 中央疲劳是一种复杂的神经症状,具有多因素的起源.
- 了解病理生理基础对于开发向治疗至关重要.
- 目前对疲劳的管理策略主要是症状和康复性.
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