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相关概念视频

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

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相关实验视频

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

胰腺癌是一种癌症.

Donghui Li1, Keping Xie, Robert Wolff

  • 1Department of Gastrointestinal Medical Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 426, Houston, TX 77030, USA.

Lancet (London, England)
|March 31, 2004
PubMed
概括

胰腺癌的预后不好,治疗选择有限,死亡率高. 了解其分子生物学方面的进步为开发更有效的疗法提供了希望.

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 癌症研究 癌症研究

背景情况:

  • 胰腺癌是一个重大的健康挑战,结果不佳.
  • 传统的治疗方法在很大程度上是无效的,大多数患者发展致命的转移.
  • 关键的危险因素包括吸烟,年龄和遗传倾向,但主要原因尚不清楚.

研究的目的:

  • 审查当前关于胰腺癌病原学的理解.
  • 讨论现有治疗方法的局限性.
  • 突出有前途的新疗法策略.

主要方法:

  • 对分子生物学进展的审查,以了解胰腺癌.
  • 分析当前的治疗方式及其息益处.
  • 探索新兴的治疗方法.

主要成果:

  • 胰腺癌的发病包括K-ras瘤基因突变和失活的瘤抑制基因.
  • 增长因素在疾病进展中起着至关重要的作用.
  • 目前的治疗方法提供了有限的生存益处,可切除病例的5年生存率约为20%.

结论:

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  • 胰腺癌仍然对当前疗法具有抗性,需要新的方法.
  • 目前正在探索一些研究方法,如手术前化学辐射和扩大使用凝胺的方法.
  • 针对胰腺癌的分子基础的治疗策略对改善患者的治疗结果有最大的希望.