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通过转基因工程的内皮原生细胞增强了新极端增生症的抑制

Deling Kong1, Luis G Melo, Abeel A Mangi

  • 1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA.

Circulation
|April 7, 2004
PubMed
概括

移植转基因内皮原生细胞 (EPC) 过度表达内皮氧化合成酶 (eNOS) 降低了血管损伤后的新极端增生症. 这种细胞疗法在治疗血管疾病方面表现有前途.

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...