使用oxo-titanium phthalocyanine识别使用奇拉式教理醇
Atsuya Muranaka1, Masako Okuda, Nagao Kobayashi
1Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, 980-8578, Japan.
Journal of the American Chemical Society
|April 9, 2004
概括
通过使用天然化合物的--甲 (TiOPc) 衍生物实现了体识别. 该方法使用TiOPc作为模板,显示对形状变化的敏感性并确定绝对配置.
科学领域:
- 协调化学 协调化学
- 整形眼镜光谱法 整形眼镜光谱法
- 有机合成 有机合成
背景情况:
- 天然的正极二醇化合物,如甲素和血素,具有固有的性.
- 可以合成和功能化氧-甲酸 (TiOPc) 衍生物.
- 体识别对于各种应用至关重要,包括制药和材料科学.
研究的目的:
- 准备和表征新型的oxo-titanium phthalocyanine (TiOPc) 衍生物,这些衍生物来自于catechin和hematoxylin.
- 为了研究TiOPc作为一种合性识别模板的潜力.
- 用手术方法确定血素的绝对配置.
主要方法:
- 使用光谱 (UV-Vis,IR,NMR) 和色谱技术合成和表征TiOPc衍生物.
- 循环二元化 (CD) 光谱学用于研究手术特征.
- 一开始的几何优化与Kuhn-Kirkwood合振荡器机制相结合.
主要成果:
- 成功制备和表征素和血氧素的TiOPc衍生物.
- 证明了TiOPc单元通过其Q转换作为有效的模板,用于通过其Q转换进行奇拉识别.
- 在Q频段区域观察到强烈的CD活性,这是由于与血素的螺旋二维复合体的形成.
- 确定了血素的绝对配置.
结论:
- TiOPc衍生物对自然的正交二醇化合物的奇拉性识别是有效的.
- 螺旋形二维复合体形成与血素诱导显著的CD活动,使绝对的配置确定.
- 开发的手术识别方法对微妙的形状变化非常敏感.
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