对于家族性高胆固醇血症的异合体儿童的动脉内心介质厚度
Albert Wiegman1, Eric de Groot, Barbara A Hutten
1Department of Paediatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
Lancet (London, England)
|April 9, 2004
概括
患有家族性高胆固醇血症的儿童从12岁开始显示出动脉内心介质厚度增加. 儿童早期的降脂治疗可以预防严重的心血管疾病.
科学领域:
- 心血管医学 心血管医学
- 儿科内分泌学 儿科内分泌学
- 临床脂质学 临床脂质学
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,导致早期发病的严重冠状动脉疾病.
- 在患有FH的儿童中,启动降脂治疗的最佳年龄尚未确定.
- Carotid intima-media 厚度 (cIMT) 是亚临床动脉样硬化的标志物.
研究的目的:
- 与未受影响的兄弟姐妹相比,评估FH异合的儿童的亚临床动脉样硬化.
- 在这个儿科群体中确定cIMT的预测因子.
主要方法:
- 在201名患有FH的儿童和80名未受影响的兄弟姐妹 (8-18岁) 中,B模式超声波用于测量动脉内心介质厚度.
- 进行了多变量分析,以确定cIMT的预测因素.
主要成果:
- 在患有FH的儿童中,cIMT的平均组合值显著大于FH (0.494毫米),而不是未受影响的兄弟姐妹 (0.472毫米) (p=0.002).
- 在患有FH的儿童中,从12岁开始观察到升高的cIMT.
- LDL胆固醇,年龄和性别是cIMT的重要独立预测因素.
结论:
- 患有FH的儿童表现出动脉样硬化的早期迹象,可通过从12岁开始增加cIMT来检测.
- LDL胆固醇是儿童FH中cIMT的关键决定因素.
- 需要进一步的临床研究来评估在患有FH的儿童中治疗他类药物的长期安全性和疗效.
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