hippocampal 记忆巩固和再巩固的独立细胞过程
Jonathan L C Lee1, Barry J Everitt, Kerrie L Thomas
1Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK.
Science (New York, N.Y.)
|April 10, 2004
概括
记忆的整合和重新整合是不同的过程. 巩固需要来自大脑的神经营养因子 (BDNF),而重新巩固涉及Zif268,揭示了记忆的单独分子机制.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 记忆研究 记忆研究
背景情况:
- 记忆的形成包括巩固,这是一个时间依赖的过程.
- 既定记忆在回忆时可能变得不稳定,需要重新巩固.
- 巩固与再巩固的分子基础仍在争论中.
研究的目的:
- 调查记忆巩固和再巩固是否是不同的分子过程.
- 确定每个记忆稳定阶段所涉及的特定分子因素.
- 澄清BDNF和Zif268在记忆巩固和再巩固中的作用.
主要方法:
- 在老鼠海马中注入反感性寡氧核酸的输液.
- 选择性操纵与记忆过程相关的基因表达.
- 行为测试以评估记忆的巩固和重新巩固.
主要成果:
- 发现记忆巩固涉及来自大脑的神经营养因子 (BDNF).
- 记忆再巩固被证明可以招募Zif268.8转录因子.
- BDNF没有参与再巩固,Zif268也没有参与巩固,表明双重解离.
结论:
- 记忆的巩固和再巩固是双重分离的过程.
- 特别需要BDNF来巩固记忆.
- Zif268在记忆再巩固中起着至关重要的作用,有助于大脑的可塑性,学习和记忆.
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