相关实验视频
Updated: Jul 15, 2026

07:15
Invasion of Human Cells by a Bacterial Pathogen
Published on: March 21, 2011
古代的入侵:从内共生体到有机体
Sabrina D Dyall1, Mark T Brown, Patricia J Johnson
1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1489, USA.
概括
细胞进化涉及古代的共生事件,其中菌变成线粒体和塑体,创造了必不可少的细胞工厂. 这些内共生生物进化了复杂的生存和融入宿主细胞的机制.
科学领域:
- 进化生物学是进化的生物学.
- 细胞生物学 细胞生物学
- 基因组学就是基因组学.
背景情况:
- 线粒体和塑体起源于超过10亿年前的细菌内共生.
- 这些细胞器对真核细胞的生物能量和生物合成功能至关重要.
研究的目的:
- 探索推动内共生体进化为有机体的分子事件.
- 了解器官进化过程中的基因组和功能转变.
主要方法:
- 地质化学分析进行.
- 分子系谱的分子系谱.
- 细胞生物学研究 细胞生物学研究
主要成果:
- 在成为有机体后,内共生动物失去了大量的基因组.
- 进化了器官生物发生和代谢物交换的复杂机制.
- 共生生物获得了宿主特征,减少了它们的eubacteria身份.
结论:
- 内共生体的整合代表了真核生物进化中的一个关键步骤.
- 器官的多样性反映了复杂的进化历史,这些历史仍在被揭露.
相关概念视频
Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Endocytosis
Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either sorted through...
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either sorted through...
Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Infection
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Microbial Interactions: Parasitism
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
Colonisation of Pathogens
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

